In Python, integers have arbitrary precision, implying that they can represent extremely large values that may not fit into standard C ssize_t or other fixed-size integer types. When you need to pass large Python integers to a C function or interface that expects ssize_t or other fixed-size integers, you need to handle the conversion carefully and possibly deal with potential overflow or loss of information. An example of how to handle this situation using the ctypes library in Python: import ctypes # large Python integer large_integer = 123456789012345678901234567890 # Convert the Python integer to a C ssize_t, handling potential overflow try: c_integer = ctypes.c_ssize_t(large_integer) print("Converted integer:", c_integer.value) except OverflowError: print("Integer is too large to convert to ssize_t") In this example, we attempt to convert the large Python integer to a ctypes c_ssize_t. If the integer is too large to fit into a ssize_t, an OverflowError will be raised, and you can handle it accordingly. An additional thing to keep in mind is that handling extremely large integers in C may not be straightforward, because fixed-size integer types like ssize_t have a limited range. If you need to work with very large integers, consider using specialized libraries or tools like GMP (GNU Multiple Precision Arithmetic Library) in C or libraries like sympy or mpmath in Python that provide arbitrary-precision arithmetic.