run exe in proton prefix
cd /path/to/steam/steamapps/compatdata/20920/pfx STEAM_COMPAT_DATA_PATH="/path/to/steam/steamapps/compatdata/20920" WINEPREFIX=$PWD \ "$HOME/.steam/root/steamapps/common/Proton 5.0/proton" run ./drive_c/path/to/custom_application.exe
Source: gist.github.com